Web2188 阅读. 锌指结构基元 (zinc finger motif) 有问题?. 丁香实验库全新大升级,10000+ 实验方法任你选. 前往丁香实验. 这类蛋白因子往往含有几个相同的指结构, 每一个指结构具有以下的保守序列: Cys-X2-4-Cys-Phe-X5-Leu-X2-His-X3-His。这段保守序列中的两个半胱氨酸残 … Web该ZKSCAN1 Polyclonal Antibody. The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links (summarized by Tommerup and Vissing, 1995 [PubMed …
Design and Selection of Novel Cys2His2 Zinc Finger Proteins
WebApr 2, 1996 · It has previously been thought that a single zinc finger of the Cys2-His2 family is incapable of specific, high-affinity binding to DNA. The combination of an N-terminal … Web分子生物学选择题及答案_试卷_生物. 创建时间 2024/04/13. 下载量 1 bj\\u0027s raleigh brier creek
Cys2His2 zinc finger protein family: classification, functions, and ...
WebDec 24, 2024 · ZFN 技术诞生于 1996 年,直到 2002 年,Bibikova 等第一次用 ZFN 的方法通过在果蝇中成功突变了 yellow 基因。ZFN 是 Cys2-His2 锌指蛋白(ZFP)和衍生自 FokI 核酸内切酶的非特异性 DNA 限制酶的融合蛋白,可靶向的 DNA 裂解试剂,已被用作基因靶向工具,ZFPs 在真核细胞中很常见,并与转录调控和蛋白质-蛋白质 ... WebApr 4, 2024 · ZBTB7A, a transcription factor containing a tandem array of four Cys2-His2 zinc fingers (ZFs), is vital for multiple physiological events through directional binding to different genomic loci. Our previously determined crystal structure of ZBTB7A in complex with a GCCCCTTCCCC sequence revealed that all the four ZFs (ZF1–4) are involved in ... Web锌指(英語: Zinc finger ),又稱鋅手指,是一种小的蛋白质 结构模体,其特征在于配合一个或多个锌 离子(Zn 2+ )以稳定折叠。 最初用来描述非洲爪蟾 卵母细胞 转录因子IIIA假说结构的手指状外观,锌指名称现在已经包含了各种不同的蛋白质结构 。 在1983年,非洲爪蟾TFIIIA最初被证明含有锌 ... dating sites sydney australia