Dynein intermediate chain 1

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August undefined, 2024

WebThe dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and other cargoes. Here, we ... WebAug 1, 2011 · Dyn2 has sequence similarity to the LC8 family of dynein light chains. The putative yeast dynein LC gene, DYN2/YDR424C/SLC1, was originally identified by searching the yeast genome for sequences similar to those of the human light chain (Dick et al., 1996b).The Dyn2 amino acid sequence is most similar to the highly conserved LC8 …

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WebMar 29, 2024 · Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer. High DLIC1 expression is associated with colon cancer; conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility Web604366 - DYNEIN, AXONEMAL, INTERMEDIATE CHAIN 1; DNAI1 - DNAI1 In a 9-year-old boy with immotile cilia syndrome unassociated with situs inversus, Pennarun et al. (1999) found compound heterozygosity for 2 mutations in the DNAI1 gene: a 1-bp insertion (T) at nucleotide +3 of the intronic splice donor sequence following exon 1, which was inherited … how does change4life increase awareness

The dynein heavy chain family - PubMed

WebMar 21, 2024 · This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The … WebJul 21, 2010 · Background Intracellular transport of cargoes including organelles, vesicles, signalling molecules, protein complexes, and RNAs, is essential for normal function of eukaryotic cells. The cytoplasmic dynein complex is an important motor that moves cargos along microtubule tracks within the cell. In mammals this multiprotein complex includes … WebApr 26, 2024 · Dynein intermediate chain 1 (IC1) engages in transporting PCV2 particles in endosomes from the cell periphery to the nucleus through direct binding to Caps. The dynein IC1 position overlaps the PCV2 Cap protein and reduces Cap expression. IC1 is recruited at the cytoplasm and translocated to the nucleus by the nuclear localization … how does change4life promote health

Recombinant Anti-Dynein intermediate chain 1/DNAI1 …

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WebWe show that human dynein light intermediate chain (DLIC) binds the N-terminal RH1 domain of JIP3, its paralog JIP4, and the lysosomal adaptor RILP. A point mutation in RH1 abrogates DLIC binding without perturbing the interaction between JIP3’s RH1 domain and kinesin heavy chain. Characterization of this separation-of-function mutation in ... WebFeb 26, 2024 · Dynein, one of three cytoskeletal motor protein families, was first identified a half century ago and got its name after the ‘dyne’ (i.e. a unit of force). Motor proteins are … how does change.org make moneyWebMar 21, 2024 · This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer … how does change healthcare work

"WebTynan, S. H., Purohit, A., Doxsey, S. J., Vallee, R. B. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J. Biol. " - Dynein intermediate chain 1

Dynein intermediate chain 1

Dynein - an overview ScienceDirect Topics

WebThus, IC1 is a novel dynein intermediate chain distinct from IC2 and IC3 and may be a multifunctional protein. The thioredoxin-related part of IC1 is more closely related to those of two redox-active Chlamydomonas light chains than thioredoxin. Antibodies were prepared against the N-terminal and middle domains of IC1 expressed as His-tagged ... WebMay 20, 2024 · Cytoplasmic dyneins are involved in vesicle transport, formation and localization of the Golgi complex, mitotic spindle assembly and positioning, nuclear migration, and chromosome movement. DYNC2LI1 is a light intermediate chain of the cytoplasmic dynein-2 complex and interacts directly with the heavy chain, DHC2 …

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WebGene ID: 128046204, updated on 28-Feb-2024. Summary Other designations. cytoplasmic dynein 1 intermediate chain 1 WebAbstract. The dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. …

WebJan 20, 2024 · Each dynein adopts an extended and slanted configuration on the doublet microtubule in which the motor domains of β-HC and γ-HC closely associate with the heavy chain tail domains and auxiliary ... WebJul 2, 2024 · Vaughan and Vallee (1995) reported the sequence of a partial cDNA encoding IC2, a human cytoplasmic dynein intermediate chain. They used the human cDNA as a probe to isolate rat IC2 cDNAs. The predicted human and rat IC2 proteins are 94% identical. Vaughan and Vallee (1995) found that there are multiple isoforms of rat IC1 and IC2 …

WebPTHR12442 DYNEIN INTERMEDIATE CHAIN 1 hit; PROSITE. View protein in PROSITE; PS50082 WD_REPEATS_2 1 hit; PS50294 WD_REPEATS_REGION 1 hit; Pfam. View … WebHere, using mRNA arrays and protein analysis, we show that the dynein subunit, DYNC1LI2 (dynein, cytoplasmic 1 light intermediate chain 2) is downregulated in cystinosis, a …

WebCoordinated movement of the dynein arms causes the entire axoneme to bend back and forth. IDAs and ODAs have different combinations of protein components (subunits) that …

WebApr 16, 2024 · Purified RILP co-precipitates with purified dynein light intermediate chain 1 (DLIC1), suggesting a direct interaction with the complex 23,35. Huntingtin and huntingtin-associated protein 1. how does change4life raise awarenessWebIntermediate chain: DYNC1I1 (IC1) DYNC2I1: DYNC1I2 (IC2) Light intermediate chain: DYNC1LI1 (LIC1) DYNC2LI1: ... If it is assumed that the cytoplasmic dynein 1 family existed before any others, then the branching order of the major dynein families supports the existence of sensory, immotile cilia/flagella as an intermediate in the evolution of ... how does change help you growWebAll lanes : Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11244] (ab166912) at 1/1000 dilution Lane 1 : Human fetal lung tissue lysate Lane 2 : Rat testis tissue lysate Lane 3 : Mouse testis tissue lysate Lane 4 : Human testis tissue lysate Lysates/proteins at … how does changing the pov affect the sceneWebThe cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light … how does change4life promote public healthWebAll lanes : Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11222] (ab156567) at 1/1000 dilution Lane 1 : Fetal brain lysate Lane 2 : Human hypothalamus lysate Lysates/proteins at 10 µg per lane. Secondary All … photo card wa transportWebHere, using mRNA arrays and protein analysis, we show that the dynein subunit, DYNC1LI2 (dynein, cytoplasmic 1 light intermediate chain 2) is downregulated in cystinosis, a lysosomal storage disorder caused by genetic defects in CTNS (cystinosin, lysosomal cystine transporter). how does changing the amplitude affect a waveWebDec 8, 2024 · Zhou J, et al. PLoS One, 2024. PMID 34679093, Free PMC Article. Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in … photo card stock paper