Human cd2 promoter

Author: ciod

August undefined, 2024

WebCCR7 Tg transgenic mice have a human CD2 antigen (CD2) promoter directing expression of a chemokine (C-C motif) receptor 7 (Ccr7) cDNA. CCR7 is a G protein-coupled receptor involved in the migration of memory T cells to from peripheral tissues … WebHuman CD2 (also known as LFA-2, for l eukocyte f unction-associated a ntigen-2) is a monomeric transmembrane glycoprotein of 45–50 kDa and a member of the Ig superfamily. It has two extracellular Ig-like domains (one V-like and one C-like) and a long, proline …

Two distinct factors interact with the promoter regions of several ...

Web23 feb. 2016 · Second, the U6 promoter driven gRNA specific for CD2 followed by the U6 terminator (U6 T). (c) ... Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, ... WebThe CD2AP002 promoter region was characterized bioinformatically. The HEK293 cells were treated with a miR-548k mimic or inhibitor and the luciferase activity of the CD2AP002 promoter and the mRNA expression of CD2AP002 were assayed. goethelab

MicroRNA-548k upregulates a spliced variant of human CD2

WebA segment of the human alpha 1-antitrypsin (alpha 1AT) 5'-flanking region comprising nucleotides -137 to -37 from the start of transcription is sufficient to drive liver-specific transcription from the homologous alpha 1AT promoter and from the heterologous SV40 promoter. In this paper we characteri … Web15 jun. 2001 · To generate CD2-EGFP +-transgenic mice, the EGFP coding sequence was placed under control of the human CD2 promoter and locus control region (Fig. 1). This strategy has been shown to result in a position-independent, copy number-dependent T cell-specific expression of the desired gene product . WebThe present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the … goethelampe

Transgenic analysis of thymocyte signal transduction

CD2 Gene - GeneCards CD2 Protein CD2 Antibody

Web1 sep. 2006 · As predicted from the activity of the human CD2 promoter, ILT2 protein was expressed at high levels on almost all peripheral T and B cells (Fig. 1 A). The cell surface expression of ILT2 was also detected on the majority of NK and NKT cells and thymocytes (Fig. 1 B and data not shown). goethe lahoreWeb10 jun. 2014 · In this study, a metallothionein gene, TaMT3, isolated from Tamarix androssowii was transformed into tobacco (Nicotiana tobacum) through Agrobacterium-mediated leaf disc method, and correctly expressed under the control of 35S promoter. Under Cd2+ stress, the transgenic tobacco showed significant increases of superoxide … goethe lake john muir wilderness

"CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. " - Human cd2 promoter

Human cd2 promoter

The Metallothionein Gene, TaMT3, from Tamarix androssowii Confers Cd2 ...

Web4 jan. 2000 · We generated transgenic mice expressing constitutively active murine CDC42 (Q61L) under the control of the human CD2 promoter. Transgenic mice showed smaller thymi with a dramatic reduction of... Web24 feb. 2024 · This subset is specialized in interleukin-12 (IL-12) production and cross-presentation of antigens that promote type 1 innate lymphoid cell (ILC1), CD4 + T helper 1 (T H 1) cell, and cytotoxic CD8 + T cell immunity ( 17 – 24 ). cDC1s are therefore essential to promote antitumor and antiviral immunity, as well as to initiate immune responses …

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Web13 apr. 2024 · Este artículo es parte de un proyecto conjunto entre un apasionado gamer y consultor estratégico, y Cassie, una herramienta de inteligencia artificial de última generación. Juntos, analizamos ... WebThe Human CD2 pGreenZeo Differentiation Reporter co-expresses dscGFP (destabilized copGFP, 2-hour half-life) and zeomycin resistance from the human CD2 promoter/enhancer elements, enabling visualization of hematopoiesis using GFP …

Web19 jul. 2024 · Interestingly, a recent report revealed that ZBTB16 is specifically upregulated in human Th17 cells possibly by RORγt, as RORγt downregulation diminishes its expression. Upon expression, ZBTB16 not only directly binds to the promoters of Ccr6 & Rorc and activates their expressions, but also collaborates with ROR γ t to induce the … WebBackground: Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. Materials and methods: We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter.

Web21 mrt. 2024 · CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Mastocytosis . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway . Gene Ontology (GO) … Complete information for ENSG00000271427 gene (RNA Gene), … Web6 jul. 2015 · Recently, one study demonstrated that the over-expression of SRG3 under the control of the human CD2 promoter exacerbated the development of EAE, suggesting that SRG3 expression in the T cell lineage significantly influences the pathogenesis of EAE . CD4 + T helper cells have been implicated in regulating autoimmune responses.

Web4 mei 2024 · 98 murine CD3ζ-GFP fusion proteins (Kumar et al., 2011) under the control of the human 99 CD2 promoter and enhancer, shown to direct T cell-specific expression from the earliest 100 stages in the thymus and onwards (Greaves, Wilson, Lang, …

Web23 dec. 1999 · We generated transgenic mice expressing constitutively active murine CDC42 (Q61L) under the control of the human CD2 promoter. Transgenic mice showed smaller thymi with a dramatic reduction of CD4+CD8+, CD4+ and CD8+ thymocytes and with increase of CD4-CD8- thymocytes at CD25-CD44+ and CD25+ stage. goethe lake fishingWeb29 mrt. 2024 · CD2 mediates activation of a distal -3.6-kilobase STAT5 binding region of the interferon-gamma promoter. We use this analysis to determine that the 2D Kd for CD2-CD58 is 5.4-7.6 molecules/microm2. 2D Kd analysis provides a general and quantitative … goethe languageWeb23 dec. 1999 · We generated transgenic mice expressing constitutively active murine CDC42 (Q61L) under the control of the human CD2 promoter. Transgenic mice showed smaller thymi with a dramatic reduction of CD4+CD8+, CD4+ and CD8+ thymocytes and … goethe language testWebAs predicted from the activity of the human CD2 promoter,ILT2 proteinwas expressedat high levels on almost all peripheral Tand B cells (Fig.1A). The cell surface expression of ILT2 was also detected on the majority of NK and NKT cells and thymocytes (Fig. 1B and data not shown). goethe laocoonWeb24 mrt. 2024 · CD58/CD2 is the primary costimulatory pathway in human CD28-CD8+ T cells. ... The polymorphisms of the proximal promoter of CD28 were not associated with systemic lupus erythematosus, ... Human postthymic regulatory T cells require CD28 costimulation to expand and maintain potent suppressive function in vivo. goethe language quoteWeb6 okt. 2024 · Tumor growth and production of ascites were inhibited in Cbx3/HP1γ-deficient mice compared to controls or mice ectopically expressing Cbx3/HP1γ driven by the human T-cell-restricted Cd2 promoter (Cbx3/HP1γ Tg) (Figures 3A, B and S2A, B). As a result, Cbx3/HP1γ-deficient mice lived longer than controls . goethe las palmasWeb1 jul. 2024 · CD2-associated protein (CD2AP) ... By scanning human CD2AP promoter in silico for sequences complementary to known miRNAs, we chose miR-939, miR-148b*, miR-191*, ... goethe language courses