WebAug 1, 2024 · The intracellular localization of RBFOX2 protein differed with disease status, with RBFOX2 localized in the cytoplasm in calcific tendons and the nucleus in normal tendons. Analysis of the RBFOX2 protein-coding sequence showed that exon 10, responsible for nuclear localization, was absent in calcific tendons. WebJun 30, 2024 · 该研究通过转录组测序分析发现,受rbfox2和golim4-l调控的基因均富集于囊泡转运信号通路;细胞生物学实验结果表明,rbfox2和golim4-l可以通过影响高尔基体的稳定性,从而影响囊泡转运通路;进一步机制研究发现,golim4-l可以与囊泡转运相关蛋白rab26相互结合,招募其进入高尔基体中,共同维持高尔基 ...
RBFOX2 protein expression summary - The Human Protein Atlas
WebJan 2, 2024 · If change in inclusion with Rbfox2 deletion was BF >5 in any of three comparisons, in vivo low-flow Rbfox2 control vs. Rbfox2 EC-KO artery at 7 days, in vivo high-flow Rbfox2 control vs. Rbfox2 EC-KO artery at 7 days, or in vitro Rbfox2 control vs. Rbfox2-deleted aortic endothelial cells, and consistently changed in the same direction in all in … WebRBFOX2. HGNC Family. RNA binding motif containing (RBM) Name. RNA binding protein, fox-1 homolog (C. elegans) 2. Description. This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other ... how fast can the fastest rapper rap
The effect of Rbfox2 modulation on retinal ... - PubMed
WebJan 7, 2024 · Protein isoform transitions confer muscle fibers with distinct properties and are regulated by differential transcription and alternative splicing. RNA-binding Fox protein 1 (Rbfox1) can affect both transcript levels and splicing, and is known to contribute to normal muscle development and physiology in vertebrates, although the detailed mechanisms … Web尽管已经有很多研究表明RBFox蛋白在心脏疾病中的作用,但影响RBFox2表达的机制还需深入研究。. 目前,对RBFox蛋白功能与机制的研究多数是借助动物模型或人类病理组织中 … WebFeb 28, 2024 · Therefore, it is still unknown how RBFOX2 as an RNA binding protein contributes to heart development. To address this, we conditionally deleted Rbfox2 in … highcroft bramber